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CLAIRITY(TM) SIA by ImageProVision, Inc.

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IMAGE ANALYTICS. REIMAGINED. SIAStatic Image AnalyzersPRODUCT SPECIFICATIONS...SIA DEPLOYMENT OPTIONS…Pune, IndiaDS IKON, 3F, Survey no. 22, LaxmanNagar, Baner, Pune 411045 INDIA+ 91 82370 39001Princeton, USAPrinceton Innovation Center BioLabs303A College Rd E, Princeton, NJ USA 08540+ 1 346.583.9212getCLAIRITY.ImageProVision.com Info@ImageProVision.comSPECIFICATIONApplication Routine Analysis/Manufacturing RCA/QC ARD/Method DevelopmentParticle Size Range (um) Nano, Subvisible, VisibleObjectives Particle Size Range (um)Particle Attributes Length, Major Axis, Minor Axis, Breadth, Feret Diameter Length, Feret Diameter Width, Feret Angle, Horizontal Feret Diameter, Vertical Feret Diameter, Width, Aspect Ratio, Area, Perimeter, Circle Equivalent Diameter, Spherical Equivalent Volume, Major Axis Angle, Convexity, Circularity, HS Circularity, Intensity, Solidity, Sharpness, Texture, Elongation, Sphericity Particle Detection Smoothing Factor, Merging Window, Agglomeration Threshold, Enhance Image Contrast, Polarized Particle Detection, Globule Pattern, Particle AppearanceOlympus Microscope Base Unit CX43 BX43 BX535MP Digital Camera✓ ✓ ✓CLAIRITY™ PARTICLE Module✓ ✓ ✓CLAIRITY™ AUTO Module ◆✓CLAIRITY™ USER Module✓ ✓ ✓White Light LED Lamp✓ ✓ ✓Bright Field Detection Method✓ ✓ ✓Dark Field Detection Method✓ ✓ ✓Diascopic (Transmitted) Illumination✓ ✓ ✓Episcopic (Reected) Illumination◆✓LED BeamSpot Oblique Angle Illuminator◆✓Polarized Light Detection Method◆ ◆Automated Sample Stage◆✓Manual Sample Stage✓ ✓21 CFR Part 11 Compliance◆ ◆ ◆Annual Software License Subscription✓ ✓ ✓Local InstallationDirect PC deployment for simplicity and ease of useLIMS InstallationNetwork deployed multi-terminal access for use across locationsCloud AccessInfrastructure free deployment with truly global access to data✓ Included ◆ Option/ Upgrade4x25 - 250010x10 - 100040x2.5 - 250100x1 - 100SIA SIA SIACLAIRITY™ PARTICLE ANALYSIS SOLUTIONS

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STATIC IMAGE ANALYSIS… ...REIMAGINED WITH SIAThe SIA family of Static Image Analyzers from ImageProVision provides vital particle characterization and visualization analysis from development through manufacturing to enhance product knowledge and improve process understanding. SIA combines the performance of an Olympus microscope platform with the sensitivity of CLAIRITY™ Particle Analysis Suite to create a high-performance imaging solution for measuring particle size and morphology in dispersed powders, suspensions, emulsions and solutions on glass slides or lter paper and in intact sample cells. Three available congurations support your workow where you need it – from high performance in development laboratories to dedicated analysis on the manufacturing oor. “With SIA from ImageProVision I could deploy three systems across my site, easily share methods and results, and accelerate review processes. Cost-effective efciency with no performance compromise.”The Static Image Analysis workow of CLAIRITY™ SIA for particle characterization and visualization on substrates or intact sample cells. Maximize efciency for dedicated analysis. Routine particle analysis in laboratory and plant QC operations. The power of CLAIRITY™ PARTICLE with an Olympus CX43 microscope.Advanced features in a cost-effective model. Excellent performance and upgradeable measurement exibility in a budget friendly package. The power of CLAIRITY™PARTICLE with an Olympus BX43 microscope. For the most challenging applications. Highest performance, automation and measurement exibility. The power of CLAIRITY™ PARTICLE, CLAIRITY™AUTO with an Olympus BX53 microscope and automated sample stage. SIA SIA SIA153 72 64 89Validate SystemThreshold & SegmentLoad & FocusClassify & ID Disperse SampleMeasure ParticlesAcquire ImagesAnalyze & ReportReview & RecordParticle characterization is a primary science in developing and manufacturing pharmaceutical products. Precise measurement of particle size and in particular, particle morphology is crucial to ensure processability, maintain quality and conrm efcacy. Static image analysis has emerged as the leading technology platform for understanding particle characteristics. Static imaging provides explicit analytical data including size, shape and texture parameters quickly and non-destructively. Static image analysis can be integrated at multiple points in the research, development and manufacture of pharmaceutical products, providing more complete and consistent particle insights from product design to manufacturing to product release.

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STATIC IMAGE ANALYSIS… ...REIMAGINED WITH SIAThe SIA family of Static Image Analyzers from ImageProVision provides vital particle characterization and visualization analysis from development through manufacturing to enhance product knowledge and improve process understanding. SIA combines the performance of an Olympus microscope platform with the sensitivity of CLAIRITY™ Particle Analysis Suite to create a high-performance imaging solution for measuring particle size and morphology in dispersed powders, suspensions, emulsions and solutions on glass slides or lter paper and in intact sample cells. Three available congurations support your workow where you need it – from high performance in development laboratories to dedicated analysis on the manufacturing oor. “With SIA from ImageProVision I could deploy three systems across my site, easily share methods and results, and accelerate review processes. Cost-effective efciency with no performance compromise.”The Static Image Analysis workow of CLAIRITY™ SIA for particle characterization and visualization on substrates or intact sample cells. Maximize efciency for dedicated analysis. Routine particle analysis in laboratory and plant QC operations. The power of CLAIRITY™ PARTICLE with an Olympus CX43 microscope.Advanced features in a cost-effective model. Excellent performance and upgradeable measurement exibility in a budget friendly package. The power of CLAIRITY™PARTICLE with an Olympus BX43 microscope. For the most challenging applications. Highest performance, automation and measurement exibility. The power of CLAIRITY™ PARTICLE, CLAIRITY™AUTO with an Olympus BX53 microscope and automated sample stage. SIA SIA SIA153 72 64 89Validate SystemThreshold & SegmentLoad & FocusClassify & ID Disperse SampleMeasure ParticlesAcquire ImagesAnalyze & ReportReview & RecordParticle characterization is a primary science in developing and manufacturing pharmaceutical products. Precise measurement of particle size and in particular, particle morphology is crucial to ensure processability, maintain quality and conrm efcacy. Static image analysis has emerged as the leading technology platform for understanding particle characteristics. Static imaging provides explicit analytical data including size, shape and texture parameters quickly and non-destructively. Static image analysis can be integrated at multiple points in the research, development and manufacture of pharmaceutical products, providing more complete and consistent particle insights from product design to manufacturing to product release.

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IMAGE ANALYTICS. REIMAGINED. SIAStatic Image AnalyzersPRODUCT SPECIFICATIONS...SIA DEPLOYMENT OPTIONS…Pune, IndiaDS IKON, 3F, Survey no. 22, LaxmanNagar, Baner, Pune 411045 INDIA+ 91 82370 39001Princeton, USAPrinceton Innovation Center BioLabs303A College Rd E, Princeton, NJ USA 08540+ 1 346.583.9212getCLAIRITY.ImageProVision.com Info@ImageProVision.comSPECIFICATIONApplication Routine Analysis/Manufacturing RCA/QC ARD/Method DevelopmentParticle Size Range (um) Nano, Subvisible, VisibleObjectives Particle Size Range (um)Particle Attributes Length, Major Axis, Minor Axis, Breadth, Feret Diameter Length, Feret Diameter Width, Feret Angle, Horizontal Feret Diameter, Vertical Feret Diameter, Width, Aspect Ratio, Area, Perimeter, Circle Equivalent Diameter, Spherical Equivalent Volume, Major Axis Angle, Convexity, Circularity, HS Circularity, Intensity, Solidity, Sharpness, Texture, Elongation, Sphericity Particle Detection Smoothing Factor, Merging Window, Agglomeration Threshold, Enhance Image Contrast, Polarized Particle Detection, Globule Pattern, Particle AppearanceOlympus Microscope Base Unit CX43 BX43 BX535MP Digital Camera✓ ✓ ✓CLAIRITY™ PARTICLE Module✓ ✓ ✓CLAIRITY™ AUTO Module ◆✓CLAIRITY™ USER Module✓ ✓ ✓White Light LED Lamp✓ ✓ ✓Bright Field Detection Method✓ ✓ ✓Dark Field Detection Method✓ ✓ ✓Diascopic (Transmitted) Illumination✓ ✓ ✓Episcopic (Reected) Illumination◆✓LED BeamSpot Oblique Angle Illuminator◆✓Polarized Light Detection Method◆ ◆Automated Sample Stage◆✓Manual Sample Stage✓ ✓21 CFR Part 11 Compliance◆ ◆ ◆Annual Software License Subscription✓ ✓ ✓Local InstallationDirect PC deployment for simplicity and ease of useLIMS InstallationNetwork deployed multi-terminal access for use across locationsCloud AccessInfrastructure free deployment with truly global access to data✓ Included ◆ Option/ Upgrade4x25 - 250010x10 - 100040x2.5 - 250100x1 - 100SIA SIA SIACLAIRITY™ PARTICLE ANALYSIS SOLUTIONS